Biotechnology Innovation Organization – I am BIO Podcast
Biotechnology Innovation Organization – I am BIO Podcast
Episode 80: Cracking the Code on Pain Relief
February 28, 2023
Imagine living with excruciating pain that prevents you from walking or doing the things most of us take for granted. We all experience pain, and 50 million people cope with chronic, debilitating pain. The market for pain therapies is estimated at $74 billion. And yet, investment in new pain and addiction treatments is falling short of what is needed, according to a new BIO report, which shows a 44% decrease in clinical drug programs for pain over the past five years. Our guests on this episode talk about the challenges of living with and treating pain, as well as research and development on new, non-addictive and safer pain therapies.
BIO CEO 2023: Despite high prevalence of pain and addiction, clinical efforts drop, funding flat, BIO report finds
BioWorld
BIO CEO 2023: Despite high prevalence of pain and addiction, clinical efforts drop, funding flat, BIO report finds
Feb. 9, 2023
The Biotechnology Innovation Organization (BIO) found in a new study that 77% of clinical programs focused on pain
therapeutics five years ago are no longer active and that financings of companies working in the space are lackluster at
best.
Meanwhile, oncology companies, targeting an overall smaller market, have raised huge sums of venture capital (VC)
money, $9.7 billion in 2021 vs. pain and addiction companies’ $228 million.
Focus and Fundamentals: CFO Strategies on the Journey to Commercialization
Pharmaceutical Executive
Focus and Fundamentals: CFO Strategies on the Journey to Commercialization
February 9, 2023
Chief financial officers and other finance experts discuss the continued market volatility impacting life sciences investment—and what biopharma companies can do to help accelerate its recovery. Quality science and “good data” still win the day.
On Dec. 1, 2022, a panel consisting of chief financial officers (CFOs) and other financial experts convened for a virtual roundtable to discuss the recent economic developments in the life sciences industry and how companies are adapting. The biopharmaceutical sector has not been immune to global economic challenges. After the COVID-19 pandemic generated a wave of new interest in the life sciences, the past year saw a retraction in the market.
Founders Keepers podcast
Founders Keepers podcast
#35 Conference Special (2/2): Dr Hernan Bazan from South Rampart Pharma
February 9, 2023
Founded in 2016, South Rampart Pharma is a clinical-stage life science company dedicated to advancing the safe treatment of pain by developing new non-opioid small molecule solutions that lack the liver and kidney toxicity present in current pain medicines. The company’s lead program, SRP-001, is currently in a Phase 1 study evaluating the safety, tolerability, and pharmacokinetics with data expected later this year in 2023.
Panel Takes on Challenges in Pain Therapeutics at BIO CEO
BioSpace
Panel Takes on Challenges in Pain Therapeutics at BIO CEO
February 9, 2023
Finding long-term, non-addictive solutions to manage chronic pain in the U.S. has long been a challenge for biopharma. In thefallout from the opioid pandemic, physicians and researchers are scrambling for options.
Tuesday, a panel of experts took on stiff questions about pain/addiction therapeutics during a panel hosted by theBiotechnology Innovation Organizaion (BIO) in New York City.
‘All hands on deck’ needed to address U.S. pain and addiction innovation
Bio.News
‘All hands on deck’ needed to address U.S. pain and addiction innovation
February 8, 2023
The number of new pain drugs in the development pipeline has slowed to a trickle and investment in addiction drugs is low, challenges addressed during an impassioned, collaborative panel, “Resetting the innovation landscape for pain and addiction therapeutics,” yesterday at BIO’s 2023 CEO and Investor Conference.
Panelists discussed potential solutions as they responded to BIO’s recent report, “The State of Innovation in Pain and Addiction,” which describes the issue in detail.
South Rampart Pharma to Present at 2023 BIO CEO & Investor Conference
Jan. 31, 2023
Hernan Bazan, MD, FACS, CEO and Co-Founder, will provide a company update
Dr. Bazan will also participate in a panel on pain therapeutics innovation with a VP of Industry Research from BIO and Program Directors from NIH and the U.S. Pain Foundation
South Rampart Pharma (“South Rampart” or the “Company”), a clinical-stage life science company advancing innovative non-opioid medications for the treatment of pain, today announced that Hernan Bazan, MD, FACS, CEO and Co-Founder of South Rampart Pharma and the Endowed John Ochsner Professor of Cardiovascular Innovation at the Ochsner Clinic, will present at the BIO CEO & Investor Conference on Monday, February 6.
Dr. Bazan’s presentation will highlight the recent company developments on its novel non-opioid lead asset, ongoing pipeline progress, clinical trial updates and anticipated milestones. Details about the presentation are as follows:
Presenter: Hernan Bazan, MD, FACS,
How to move past the opioid crisis
Washington Examiner
How to move past the opioid crisis
January 22, 2023
Drug overdoses accounted for more than 109,000 deaths in 2021 in the United States , an astounding 43% surge from 76,000 deaths just the year before. A recent study predicted another 1.2 million opioid overdose deaths by the end of this decade.
Scrip Asks…What Does 2023 Hold For Biopharma? Part2: M&A And Partnering
Scrip Pharma Intelligence
Scrip Asks…What Does 2023 Hold For Biopharma? Part2: M&A And Partnering
January 9, 2023
Hernan Bazan, CEO of South Rampart Pharma, which is developing small molecules for pain relief, also commented on the benefits of in-person get-togethers, although he acknowledged the perks of virtual interaction when it comes to partnering. “I think hybrid approaches will continue in 2023. Following the pandemic, my first in-person partnering meeting was BIO in June 2022 (San Diego), and there was palpable excitement to meet face-to-face. Though deals can be done virtually, personal interaction allows a connection to be made when technology and partnering tactics are discussed. Virtual meeting platforms allow for efficient use of time when doing more technical reviews,” he said.
“For these reasons, I feel the hybrid approach is here to stay. I think partnering through option license deals for promising technologies – particularly those with clinically
January 2023 Issue: A New Funding Model For A New Approach To Pain
Life Science Leader
January 2023 Issue: A New Funding Model For A New Approach To Pain
January 3, 2023
Painkillers are a challenge for the pharma and healthcare industries or, said differently, ripe for innovation. Two of the most popular pain reduction treatments are opioids and NSAIDs (non-steroidal anti-inflammatory drugs). Sadly, both have issues.
Current Lack of Innovation in the Pain Space Hurts Society
MedCity News
Current Lack of Innovation in the Pain Space Hurts Society
December 22, 2022
The future towards the safer treatment of pain will come as biopharma, and investor communities appreciate the significant opportunities in supporting scientifically rigorous and clinically validated lead assets for the safer treatment of pain.
Current pain medications are addictive (opioids), or potentially damaging to the liver (acetaminophen/Tylenol or kidneys with substantial gastrointestinal toxicity (nonsteroidal anti-inflammatory drugs, NSAIDs).
Tales From the 2022 Biotech VC Fundraising Trail
The Wall Street Journal
Tales From the 2022 Biotech VC Fundraising Trail
December 22, 2022
After the bonanza of 2021, life-sciences entrepreneurs reset their expectations as financing contracted
Biotechnology entrepreneurs recalibrated in 2022 as their financing options narrowed, a reversal from years in which life-sciences startups were flush with capital.
With just two weeks left in the year, U.S. biotechs had raked in $29.7 billion for 2022, compared with the record—$38.7 billion—deployed in all of 2021, according to market tracker PitchBook Data Inc.
Wellbeing Checkup
Medical World News
Wellbeing Checkup
December 9, 2022
It is estimated that up to 20% of US adults are dealing with chronic pain and 8% of US Adults have high-impact chronic pain. Dr. Hernan Bazan discusses the issues associated with suffering from chronic pain and daily use of opioids, offers some insights on traditional pain relievers, and how the next generation of therapies in development need to be a safe, potential alternative from opioids.
Non-toxic and addiction free: The promise of a new pain med
PharmaVoice
Non-toxic and addiction free: The promise of a new pain med
December 2, 2022
Why South Rampart Pharma’s novel new molecule could be a key to solving the global pain epidemic.
Pain relief without toxicity or addiction could become a reality, and South Rampart Pharma’s father-son, surgeons-turned-entrepreneurs duo could hold the key. Dr. Hernan Bazan, CEO and co-founder of the clinical stage pain company, believes it’s on the right track to capitalize not only on a market that is predicted to be valued at $90 billion by 2026, but help the 20% of adults worldwide who suffer from chronic pain.
South Rampart Pharma Announces Presentation at Arrowhead’s 16th Annual Pain Therapeutics Summit
Oct. 21, 2022
South Rampart Pharma (“South Rampart” or the “Company”), a clinical-stage life science company advancing innovative medications for the treatment of pain, today announced that Hernan Bazan, MD, FACS, CEO and Co-Founder of South Rampart Pharma and the Endowed John Ochsner Professor of Cardiovascular Innovation at the Ochsner Clinic, will present at Arrowhead’s 16th Annual Pain Therapeutics Summit.
Taking place in Washington, DC, on November 14-15, 2022, the Pain Therapeutics Summit is the US’s premier conference covering pain research and emerging therapeutics. Leaders from the biopharmaceutical industry, academia, and the NIH attend the conference to learn about the latest advances in treating various kinds of pain and network with colleagues from industry, academia, clinical research organizations, and government.
Dr. Bazan’s presentation, “Overcoming the Liver Toxicity Associated with Acetaminophen Via a New Class of Small Molecule Non-Opioids,” will highlight the ongoing clinical development of novel non-opioid small molecule SRP-001 for the treatment
South Rampart Pharma Issued Composition of Matter Patent for Novel Non-Toxic Treatment for Pain
Oct. 4, 2022
– New patent grant further secures South Rampart’s competitive position in next-generation and disruptive investigational drugs for acute pain –
South Rampart Pharma (“South Rampart” or the “Company”), a clinical-stage life science company advancing innovative medications for the treatment of pain, today announced the issuance of a composition of matter US patent No. 11,458,142 for its novel, non-opioid, and non-liver toxic treatments for pain. The issued patent covers a library of novel small molecules, including the Company’s lead program, SRP-001, which is currently being studied in a two-part randomized, double-blind, placebo-controlled study Phase 1 study evaluating safety, tolerability, and pharmacokinetics, with data expected early in 2023.
This issued patent adds to the Company’s growing patent portfolio, which includes ‘Compositions and methods for ameliorating pain and reducing fever’ US patent No. 11,007,199. The Composition of Matter patent issued today has been nationalized in key world markets. South
South Rampart Pharma Receives Year 3 of NIH Fast-Track STTR Commercialization Grant
Sept. 22, 2022
South Rampart Pharma (“South Rampart” or the “Company”), a clinical-stage life science company advancing innovative medications for the treatment of pain and fever, today announced that it received a Notice of Award from the National Institutes of Health (NIH) regarding Year 3 of its Small Business Technology Transfer (STTR) grant.
The NIH grant is entitled ‘Novel non-narcotic analgesic for acute and chronic pain.’ South Rampart Pharma will receive the Year 3 incremental Award of the $1.9M grant administered through the NIH’s National Institute of Neurological Disorders and Stroke (NINDS), which will continue to help support the development of SRP-001, the Company’s lead drug candidate.
SRP-001 is a novel, non-opioid small molecule with the potential to overcome many risks associated with current pain medicines, including the liver toxicity of acetaminophen. Importantly, SRP-001 mirrors acetaminophen’s clinically validated mechanism of action while simultaneously muting the biological activity that causes liver toxicity. South Rampart Pharma is
A New Pain Treatment Requires Accurate And Reliable Data, South Rampart Pharma on Featured on Clinical Leader piece.
Clinical Leader
A New Pain Treatment Requires Accurate And Reliable Data, South Rampart Pharma on Featured on Clinical Leader piece.
September 22, 2022
South Rampart Pharma aims to deliver a new, affordable treatment for pain that will avoid the issues with currently marketed products. Opioids are highly addictive; patients taking excessive amounts of acetaminophen can develop liver toxicity; and NSAID over-exposure risks kidney toxicity, gastrointestinal (GI) bleeding, and worsening of high blood pressure in patients with hypertension.
Co-founder & CEO, Dr. Hernan Bazan, speaks with Dr. Moira Gunn in NPR’s Tech Nation Radio about the need for pain relief innovation.
TechNation Radio Podcast
Co-founder & CEO, Dr. Hernan Bazan, speaks with Dr. Moira Gunn in NPR’s Tech Nation Radio about the need for pain relief innovation.
September 2, 2022
Dr. Hernan Bazan, the Co-Founder & CEO of South Rampart Pharma Featured on Tech Nation Radio Episode 22-36 Bigotry, justice and environmental pollution
South Rampart Pharma Announces Late-Breaking Presentation at IASP 2022 World Congress on Pain
Aug. 25, 2022
South Rampart Pharma (“South Rampart” or the “Company”), a clinical-stage life science company advancing innovative medications for the treatment of pain and fever, today announced that the Company will present a late-breaking abstract at the International Association for the Study of Pain (IASP) 2022 World Congress on Pain, which will take place on September 20-23, 2022, in Toronto, Canada.
The late-breaking presentation, entitled “Novel Non-Opioid Analgesic for Acute and Chronic Pain: From Discovery to Phase 1 Trial,” will chronicle the invention and development of SRP-001 (previously known as SRP-3D (DA)). Central to SRP-001’s therapeutic differentiation, this non-opioid investigational pain medication exhibits comparable, if not better, efficacy as similar approved drugs but notably does not exhibit their liver or kidney toxicity. South Rampart’s CEO and Co-founder, Hernan Bazan, MD, FACS, will deliver the presentation.
“I’m delighted to have this opportunity to showcase the groundbreaking work we’ve done with SRP-001,” commented Dr. Bazan. “Liver toxicity
South Rampart Pharma Announces Appointment of Josh Blacher as Chief Financial Officer
Aug. 16, 2022
South Rampart Pharma (“South Rampart” or the “Company”), a clinical-stage life science company advancing innovative medications for the treatment of pain and fever, today announced the appointment of Josh Blacher as the company’s Chief Financial Officer. In this capacity, Mr. Blacher will be responsible for the Company’s finance and accounting department, as well as launch a robust corporate development effort.
Mr. Blacher brings to South Rampart Pharma over twenty years of leadership experience in senior positions in the healthcare and capital markets sectors. Hernan Bazan, M.D., F.A.C.S., CEO and Co-Founder of South Rampart Pharma and The Endowed John Ochsner Professor of Surgery at the Ochsner Clinic, commented, “We are thrilled to welcome Josh to our team. Josh brings us a valuable combination of executing growth capital initiatives as well as strategic collaborations with biopharmaceutical partners.” Dr. Bazan continued, “As we ready for Phase 2 clinical trials of our novel non-opioid
South Rampart Pharma Hopes to Develop Safer Pain Medications
Biz New Orleans
South Rampart Pharma Hopes to Develop Safer Pain Medications
June 14, 2022
South Rampart Pharma, a clinical-stage life science company advancing medications for the treatment of pain and fever, announced it achieved milestones outlined in the Phase I portion of its Small Business Technology Transfer (STTR) grant (1R42NS119103) received from the National Institutes of Health (NIH) and advanced to the Phase II portion of its NIH grant. The “fast-track” combined Phase I/II award provides for $1.9 million of funding to support the ongoing clinical development of the company’s lead small molecule, SRP-3D (DA), a novel non-opioid therapeutic candidate. South Rampart Pharma currently is completing the single ascending dose phase of the Phase 1 clinical trial of SRP-3D (DA) and remains on track to report topline results from the study in the third quarter of 2022.
South Rampart Pharma on Empowered Patient Podcast with Karen Jagoda and Dr. Hernan Bazan.
Empowered Patient Podcast
South Rampart Pharma on Empowered Patient Podcast with Karen Jagoda and Dr. Hernan Bazan.
June 8, 2022
Developing a Non-Opioid Small Molecule Pain Medicine To Overcome the Risks of Organ Toxicity and Abuse.
South Rampart Pharma Achieves Development Milestone and Advances to Phase II of Active NIH Fast-Track STTR Commercialization Award
May 4, 2022
$1.9 million NIH fast-track STTR grant fuels next stage of clinical program dedicated to the development of a novel non-opioid approach to pain management
Lead program SRP-3D (DA) advances in ongoing Phase 1 clinical trial with data expected in the third quarter of 2022
South Rampart Pharma (“South Rampart” or the “Company”), a clinical-stage life science company advancing innovative medications for the treatment of pain and fever, today announced it achieved milestones outlined in the Phase I portion of its Small Business Technology Transfer (STTR) grant (1R42NS119103) received from the National Institutes of Health (NIH) and advanced to the Phase II portion of its NIH grant. The ‘fast-track’ combined Phase I/II award provides for $1.9 million of funding to support the ongoing clinical development of the Company’s lead small molecule, SRP-3D (DA), a novel non-opioid therapeutic candidate. South Rampart Pharma currently is completing the single
South Rampart Pharma Announces Patient Enrollment and Dosing Underway in Phase 1 Study Evaluating Novel Non-Opioid Approach to Pain with Lead Program, SRP-3D (DA)
March 23, 2022
SRP-3D (DA) has demonstrated a compelling safety profile over currently available pain medications
Potential to address the significant unmet need for new, safe, effective, and non-opioid pain medications
Development program funded by the National Institutes of Health (NIH) through a Small Business Technology Transfer (STTR) Fast Track Grant
Topline results expected Q3 2022
South Rampart Pharma (“South Rampart” or the “Company”), a clinical-stage life science company focused on advancing innovative medications for the treatment of pain and fever, announced today patient enrollment and dosing in its Phase 1 study evaluating SRP-3D (DA) for pain is underway.
“We are committed to improving the lives of people suffering from acute, chronic, or neuropathic pain by developing a new class of small molecule, non-opioid pain medicines. To date, SRP-3D (DA) has shown promising efficacy in reducing both pain and fever while lacking the liver and kidney toxicity associated
South Rampart Pharma Invited to Participate in 2021 NIH Innovation Conference & Life Sciences Summit
NOLABA News
South Rampart Pharma Invited to Participate in 2021 NIH Innovation Conference & Life Sciences Summit
August 20, 2021
Exciting news for local company South Pharma! They’ve been selected to participate in the 2021 NIH Innovation Conference (NIC – a half-day, virtual event on Monday, Oct. 4) and Life Science Summit (LSS – a two-day virtual event Tuesday, Nov. 9 and Wednesday, Nov. 10) that connects innovation, capital, and industry.
See Q&A below with Company co-founder Dr. Hernan A. Bazan.
How do you feel about being selected to participate in the NIH Conference?
It’s obviously a great recognition of the hard science behind the venture. In 2020 we were able to compete with top groups from the major academic and entrepreneurial centers around the U.S. and an NIH (NINDS) Commercialization grant we submitted was scored highly and was funded. The NIH leadership has seen the progress in the past year and has
LSU HSCNO Spin-Out Awarded $1.9M in STTR Fast Track Funding
LSU Health New Orleans
LSU HSCNO Spin-Out Awarded $1.9M in STTR Fast Track Funding
September 28, 2020
The National Institute of Neurological Disorders and Stroke of the National Institutes of Health (NIH) has awarded a $1.9 million Fast-Track Small Business Technology Transfer (STTR) grant to South Rampart Pharma. The New Orleans life science company is developing a new class of non-opioid medicines to relieve pain and reduce fever discovered at and licensed from LSU Health New Orleans, its formal collaborating research institution.
NIH Awards $1.9 million STTR Grant to Fast Track New Class of Non-Opioid Pain Relievers
News-Medical.Net
NIH Awards $1.9 million STTR Grant to Fast Track New Class of Non-Opioid Pain Relievers
September 25, 2020
The National Institute of Neurological Disorders and Stroke of the National Institutes of Health (NIH) has awarded a $1.9 million Fast-Track Small Business Technology Transfer (STTR) grant to South Rampart Pharma. The New Orleans life science company is developing a new class of non-opioid medicines to relieve pain and reduce fever discovered at and licensed from LSU Health New Orleans, its formal collaborating research institution.
NIH STTR Grant To Fast Track New Class Of Pain Reliever Without Addiction Or Toxicity
Sep 25, 2020
The National Institute of Neurological Disorders and Stroke of the National Institutes of Health (NIH) has awarded a $1.9 million Fast-Track Small Business Technology Transfer (STTR) grant to South Rampart Pharma. The New Orleans life science company is developing a new class of non-opioid medicines to relieve pain and reduce fever discovered at and licensed from LSU Health New Orleans, its formal collaborating research institution.
The grant will fund late-stage, pre-clinical development of the new analgesic/antipyretic and will also support continued collaboration with LSU Health New Orleans Neuroscience Center of Excellence on pain mechanisms. A paper describing the patented new drug was recently published in the European Journal of Medicinal Chemistry.
“The safe treatment of acute and chronic pain is one of the most prevalent and costly public health issues worldwide,” said Hernan Bazan, MD, DFSVS, FACS, CEO and co-founder of South Rampart Pharma, and Professor of Surgery at the Ochsner
Novel Analgesic for Pain Relief Lacks Liver Toxicity
PainRelief.com
Novel Analgesic for Pain Relief Lacks Liver Toxicity
July 24, 2020
Thank you for your kind invitation and opportunity to commend on our paper in press in the European Journal of Medicinal Chemistry entitled ‘A novel pipeline of 2-(benzenesulfonamide)-N-(4-hydroxyphenyl) acetamide analgesics that lack hepatotoxicity and retain antipyresis.’ This is the culmination of a multi-disciplinary effort involving investigators from the United States in Spain in search for a solution to the problem of treating pain more safely.
Researchers Find Alternatives for Acetaminophen Without Liver, Kidney Effects
AJMC
Researchers Find Alternatives for Acetaminophen Without Liver, Kidney Effects
July 20, 2020
The coronavirus disease 2019 pandemic presents a new challenge: patients have severe flu-like symptoms, but the virus can also cause renal failure. Doctors and patients need analgesics that go easy on the liver and kidneys but are not addictive, and this week researchers at LSU Health New Orleans Neuroscience Center of Excellence announced they have discovered a new class of drugs that can do the job.
South Rampart Pharma Identifies New Class of Non-Opioid Pain Medicines in European Journal of Medicinal Chemistry Publication
July 10, 2020
South Rampart Pharma, LLC (“South Rampart” or “the Company”), a company committed to improving the lives of people suffering from pain by developing a new class of non-opioid pain medicines, today announced a peer-reviewed publication detailing the identification and characterization of a new class of compounds able to reduce pain and fever without abuse potential or the liver and kidney toxicity associated with over the counter pain medicines such as acetaminophen. The paper, published in the European Journal of Medicinal Chemistry, is available as open access and entitled, “A novel pipeline of 2-(benzenesulfonamide)-N-(4-hydroxyphenyl) acetamide analgesics that lack hepatotoxicity and retain antipyresis1.”
“We are currently working to finalize the preclinical data package necessary to submit our lead molecule for the first Investigational New Drug (IND) application by the third quarter of 2020, followed by the rapid initiation of Phase 1 clinical trials to evaluate safety. Ongoing preclinical studies have
South Rampart Pharma Identifies New Class of Non-Opioid Pain Medicines in European Journal of Medicinal Chemistry Publication
BioSpace
South Rampart Pharma Identifies New Class of Non-Opioid Pain Medicines in European Journal of Medicinal Chemistry Publication
July 14, 2020
South Rampart Pharma, LLC (“South Rampart” or “the Company”), a company committed to improving the lives of people suffering from pain by developing a new class of non-opioid pain medicines, today announced a peer-reviewed publication detailing the identification and characterization of a new class of compounds able to reduce pain and fever without abuse potential or the liver and kidney toxicity associated with over the counter pain medicines such as acetaminophen.
Research Roundup: COVID-19 Immunity, Stomach Acid Susceptibility and More
BioSpace
Research Roundup: COVID-19 Immunity, Stomach Acid Susceptibility and More
July 10, 2020
Investigators at LSU Health New Orleans Neuroscience Center of Excellence identified a new class of pipeline drugs to relieve pain and reduce fever. Furthermore, they appear to have decreased risk of addiction or damage to the liver or kidneys. In two models, the drugs, which are similar to acetaminophen, but do not appear to damage the liver or kidneys, decreased pain and reduced fever. The intellectual property has been licensed from LSU to the life science startup South Rampart Pharma, which is working to develop the drug in late preclinical development.
Researchers Developing Safer Version of Acetaminophen
Pain News Network
Researchers Developing Safer Version of Acetaminophen
July 8, 2020
Researchers at Louisiana State University have created a new type of analgesic that is similar to acetaminophen but can relieve pain and reduce fever without the risk of liver or kidney damage.
Novel class of non-addictive analgesics demonstrate safety in animals
Drug Target Review
Novel class of non-addictive analgesics demonstrate safety in animals
July 7, 2020
To overcome the issues of current analgesics, researchers reveal a new class of non-narcotic pipeline drugs based on acetaminophen. Acute and chronic pain management is a growing global health burden. With the opioid epidemic still on the rise, and nephro- and hepatotoxicity linked to prolonged use of non-narcotic pain medications, novel analgesics (pain killers) are desperately needed.
Team Synthesizes Safer Nonaddictive Analgesics
Technology Networks
Team Synthesizes Safer Nonaddictive Analgesics
July 7, 2020
Researchers at LSU Health New Orleans Neuroscience Center of Excellence and colleagues have discovered a new class of pipeline drugs to relieve pain and reduce fever without the danger of addiction or damage to the liver or kidneys. The research is published online in the European Journal of Medicinal Chemistry.
Safer Class of Painkillers Identified
MedNews
Safer Class of Painkillers Identified
July 7, 2020
A new class of pain medication has been identified which has a lower risk for addiction or to cause damage to internal organs. This discovery was reported by researchers at LSU Health New Orleans Neuroscience Center of Excellence and published online. The hope is that they will be safer than opioids and more effective.
They discover a new class of pain relievers that do not harm the liver or kidneys
Infosalus
They discover a new class of pain relievers that do not harm the liver or kidneys
July 7, 2020
Researchers at LSU Health’s New Orleans Center of Excellence in Neuroscience have discovered a new class of pain relievers to relieve pain and reduce fever without the danger of addiction or liver or kidney damage.
A new class of pipeline drugs to relieve pain and reduce fever without the danger of addiction or damage
Innovation Toronto
A new class of pipeline drugs to relieve pain and reduce fever without the danger of addiction or damage
July 6, 2020
Researchers at LSU Health New Orleans Neuroscience Center of Excellence and colleagues have discovered a new class of pipeline drugs to relieve pain and reduce fever without the danger of addiction or damage to the liver or kidneys. The research is published online in the European Journal of Medicinal Chemistry.
LSU Health New Orleans discovers new class of safer analgesics
EurekAlert!
LSU Health New Orleans discovers new class of safer analgesics
July 6, 2020
Researchers at LSU Health New Orleans Neuroscience Center of Excellence and colleagues have discovered a new class of pipeline drugs to relieve pain and reduce fever without the danger of addiction or damage to the liver or kidneys. The research is published online in the European Journal of Medicinal Chemistry. Current drugs have unwanted side effects. Opioids can not only cause addiction; recent studies have shown they can be no more effective at relieving pain than non-narcotic drugs. Non-steroidal anti-inflammatories (NSAIDs) can cause kidney damage. Acetaminophen is an effective drug, but overuse can result in liver damage.
LSU Health New Orleans Discovers New Class of Safer Analgesics
Jul 6, 2020
Researchers at LSU Health New Orleans Neuroscience Center of Excellence and colleagues have discovered a new class of pipeline drugs to relieve pain and reduce fever without the danger of addiction or damage to the liver or kidneys. The research is published online in the European Journal of Medicinal Chemistry.
Current drugs have unwanted side effects. Opioids can not only cause addiction; recent studies have shown they can be no more effective at relieving pain than non-narcotic drugs. Non-steroidal anti-inflammatories (NSAIDs) can cause kidney damage. Acetaminophen is an effective drug, but overuse can result in liver damage.
The research team, led by Drs. Hernan A. Bazan, a professor in the Department of Surgery and Program Director of the Vascular Surgery Fellowship at Ochsner Clinic, and Surjyadipta Bhattacharjee, a post-doctoral researcher at the LSU Health New Orleans Neuroscience Center of Excellence, set out to discover what causes the liver damage associated with
New class of safer analgesics discovered
ScienceDaily
New class of safer analgesics discovered
July 6, 2020
Researchers at LSU Health New Orleans Neuroscience Center of Excellence and colleagues have discovered a new class of pipeline drugs to relieve pain and reduce fever without the danger of addiction or damage to the liver or kidneys. The research is published online in the European Journal of Medicinal Chemistry. Current drugs have unwanted side effects. Opioids can not only cause addiction; recent studies have shown they can be no more effective at relieving pain than non-narcotic drugs. Non-steroidal anti-inflammatories (NSAIDs) can cause kidney damage. Acetaminophen is an effective drug, but overuse can result in liver damage.
A novel pipeline of 2-(benzenesulfonamide)-N-(4-hydroxyphenyl) acetamide analgesics that lack hepatotoxicity and retain antipyresis
European Journal of Medicinal Chemistry Sept 2020
Biotechnology Innovation Organization – I am BIO Podcast
Biotechnology Innovation Organization – I am BIO Podcast
Episode 80: Cracking the Code on Pain Relief
February 28, 2023
Imagine living with excruciating pain that prevents you from walking or doing the things most of us take for granted. We all experience pain, and 50 million people cope with chronic, debilitating pain. The market for pain therapies is estimated at $74 billion. And yet, investment in new pain and addiction treatments is falling short of what is needed, according to a new BIO report, which shows a 44% decrease in clinical drug programs for pain over the past five years. Our guests on this episode talk about the challenges of living with and treating pain, as well as research and development on new, non-addictive and safer pain therapies.
BIO CEO 2023: Despite high prevalence of pain and addiction, clinical efforts drop, funding flat, BIO report finds
BioWorld
BIO CEO 2023: Despite high prevalence of pain and addiction, clinical efforts drop, funding flat, BIO report finds
Feb. 9, 2023
The Biotechnology Innovation Organization (BIO) found in a new study that 77% of clinical programs focused on pain
therapeutics five years ago are no longer active and that financings of companies working in the space are lackluster at
best.
Meanwhile, oncology companies, targeting an overall smaller market, have raised huge sums of venture capital (VC)
money, $9.7 billion in 2021 vs. pain and addiction companies’ $228 million.
Focus and Fundamentals: CFO Strategies on the Journey to Commercialization
Pharmaceutical Executive
Focus and Fundamentals: CFO Strategies on the Journey to Commercialization
February 9, 2023
Chief financial officers and other finance experts discuss the continued market volatility impacting life sciences investment—and what biopharma companies can do to help accelerate its recovery. Quality science and “good data” still win the day.
On Dec. 1, 2022, a panel consisting of chief financial officers (CFOs) and other financial experts convened for a virtual roundtable to discuss the recent economic developments in the life sciences industry and how companies are adapting. The biopharmaceutical sector has not been immune to global economic challenges. After the COVID-19 pandemic generated a wave of new interest in the life sciences, the past year saw a retraction in the market.
Founders Keepers podcast
Founders Keepers podcast
#35 Conference Special (2/2): Dr Hernan Bazan from South Rampart Pharma
February 9, 2023
Founded in 2016, South Rampart Pharma is a clinical-stage life science company dedicated to advancing the safe treatment of pain by developing new non-opioid small molecule solutions that lack the liver and kidney toxicity present in current pain medicines. The company’s lead program, SRP-001, is currently in a Phase 1 study evaluating the safety, tolerability, and pharmacokinetics with data expected later this year in 2023.
Panel Takes on Challenges in Pain Therapeutics at BIO CEO
BioSpace
Panel Takes on Challenges in Pain Therapeutics at BIO CEO
February 9, 2023
Finding long-term, non-addictive solutions to manage chronic pain in the U.S. has long been a challenge for biopharma. In thefallout from the opioid pandemic, physicians and researchers are scrambling for options.
Tuesday, a panel of experts took on stiff questions about pain/addiction therapeutics during a panel hosted by theBiotechnology Innovation Organizaion (BIO) in New York City.
‘All hands on deck’ needed to address U.S. pain and addiction innovation
Bio.News
‘All hands on deck’ needed to address U.S. pain and addiction innovation
February 8, 2023
The number of new pain drugs in the development pipeline has slowed to a trickle and investment in addiction drugs is low, challenges addressed during an impassioned, collaborative panel, “Resetting the innovation landscape for pain and addiction therapeutics,” yesterday at BIO’s 2023 CEO and Investor Conference.
Panelists discussed potential solutions as they responded to BIO’s recent report, “The State of Innovation in Pain and Addiction,” which describes the issue in detail.
How to move past the opioid crisis
Washington Examiner
How to move past the opioid crisis
January 22, 2023
Drug overdoses accounted for more than 109,000 deaths in 2021 in the United States , an astounding 43% surge from 76,000 deaths just the year before. A recent study predicted another 1.2 million opioid overdose deaths by the end of this decade.
Scrip Asks…What Does 2023 Hold For Biopharma? Part2: M&A And Partnering
Scrip Pharma Intelligence
Scrip Asks…What Does 2023 Hold For Biopharma? Part2: M&A And Partnering
January 9, 2023
Hernan Bazan, CEO of South Rampart Pharma, which is developing small molecules for pain relief, also commented on the benefits of in-person get-togethers, although he acknowledged the perks of virtual interaction when it comes to partnering. “I think hybrid approaches will continue in 2023. Following the pandemic, my first in-person partnering meeting was BIO in June 2022 (San Diego), and there was palpable excitement to meet face-to-face. Though deals can be done virtually, personal interaction allows a connection to be made when technology and partnering tactics are discussed. Virtual meeting platforms allow for efficient use of time when doing more technical reviews,” he said.
“For these reasons, I feel the hybrid approach is here to stay. I think partnering through option license deals for promising technologies – particularly those with clinically
January 2023 Issue: A New Funding Model For A New Approach To Pain
Life Science Leader
January 2023 Issue: A New Funding Model For A New Approach To Pain
January 3, 2023
Painkillers are a challenge for the pharma and healthcare industries or, said differently, ripe for innovation. Two of the most popular pain reduction treatments are opioids and NSAIDs (non-steroidal anti-inflammatory drugs). Sadly, both have issues.
Current Lack of Innovation in the Pain Space Hurts Society
MedCity News
Current Lack of Innovation in the Pain Space Hurts Society
December 22, 2022
The future towards the safer treatment of pain will come as biopharma, and investor communities appreciate the significant opportunities in supporting scientifically rigorous and clinically validated lead assets for the safer treatment of pain.
Current pain medications are addictive (opioids), or potentially damaging to the liver (acetaminophen/Tylenol or kidneys with substantial gastrointestinal toxicity (nonsteroidal anti-inflammatory drugs, NSAIDs).
Tales From the 2022 Biotech VC Fundraising Trail
The Wall Street Journal
Tales From the 2022 Biotech VC Fundraising Trail
December 22, 2022
After the bonanza of 2021, life-sciences entrepreneurs reset their expectations as financing contracted
Biotechnology entrepreneurs recalibrated in 2022 as their financing options narrowed, a reversal from years in which life-sciences startups were flush with capital.
With just two weeks left in the year, U.S. biotechs had raked in $29.7 billion for 2022, compared with the record—$38.7 billion—deployed in all of 2021, according to market tracker PitchBook Data Inc.
Wellbeing Checkup
Medical World News
Wellbeing Checkup
December 9, 2022
It is estimated that up to 20% of US adults are dealing with chronic pain and 8% of US Adults have high-impact chronic pain. Dr. Hernan Bazan discusses the issues associated with suffering from chronic pain and daily use of opioids, offers some insights on traditional pain relievers, and how the next generation of therapies in development need to be a safe, potential alternative from opioids.
Non-toxic and addiction free: The promise of a new pain med
PharmaVoice
Non-toxic and addiction free: The promise of a new pain med
December 2, 2022
Why South Rampart Pharma’s novel new molecule could be a key to solving the global pain epidemic.
Pain relief without toxicity or addiction could become a reality, and South Rampart Pharma’s father-son, surgeons-turned-entrepreneurs duo could hold the key. Dr. Hernan Bazan, CEO and co-founder of the clinical stage pain company, believes it’s on the right track to capitalize not only on a market that is predicted to be valued at $90 billion by 2026, but help the 20% of adults worldwide who suffer from chronic pain.
A New Pain Treatment Requires Accurate And Reliable Data, South Rampart Pharma on Featured on Clinical Leader piece.
Clinical Leader
A New Pain Treatment Requires Accurate And Reliable Data, South Rampart Pharma on Featured on Clinical Leader piece.
September 22, 2022
South Rampart Pharma aims to deliver a new, affordable treatment for pain that will avoid the issues with currently marketed products. Opioids are highly addictive; patients taking excessive amounts of acetaminophen can develop liver toxicity; and NSAID over-exposure risks kidney toxicity, gastrointestinal (GI) bleeding, and worsening of high blood pressure in patients with hypertension.
Co-founder & CEO, Dr. Hernan Bazan, speaks with Dr. Moira Gunn in NPR’s Tech Nation Radio about the need for pain relief innovation.
TechNation Radio Podcast
Co-founder & CEO, Dr. Hernan Bazan, speaks with Dr. Moira Gunn in NPR’s Tech Nation Radio about the need for pain relief innovation.
September 2, 2022
Dr. Hernan Bazan, the Co-Founder & CEO of South Rampart Pharma Featured on Tech Nation Radio Episode 22-36 Bigotry, justice and environmental pollution
South Rampart Pharma Hopes to Develop Safer Pain Medications
Biz New Orleans
South Rampart Pharma Hopes to Develop Safer Pain Medications
June 14, 2022
South Rampart Pharma, a clinical-stage life science company advancing medications for the treatment of pain and fever, announced it achieved milestones outlined in the Phase I portion of its Small Business Technology Transfer (STTR) grant (1R42NS119103) received from the National Institutes of Health (NIH) and advanced to the Phase II portion of its NIH grant. The “fast-track” combined Phase I/II award provides for $1.9 million of funding to support the ongoing clinical development of the company’s lead small molecule, SRP-3D (DA), a novel non-opioid therapeutic candidate. South Rampart Pharma currently is completing the single ascending dose phase of the Phase 1 clinical trial of SRP-3D (DA) and remains on track to report topline results from the study in the third quarter of 2022.
South Rampart Pharma on Empowered Patient Podcast with Karen Jagoda and Dr. Hernan Bazan.
Empowered Patient Podcast
South Rampart Pharma on Empowered Patient Podcast with Karen Jagoda and Dr. Hernan Bazan.
June 8, 2022
Developing a Non-Opioid Small Molecule Pain Medicine To Overcome the Risks of Organ Toxicity and Abuse.
South Rampart Pharma Invited to Participate in 2021 NIH Innovation Conference & Life Sciences Summit
NOLABA News
South Rampart Pharma Invited to Participate in 2021 NIH Innovation Conference & Life Sciences Summit
August 20, 2021
Exciting news for local company South Pharma! They’ve been selected to participate in the 2021 NIH Innovation Conference (NIC – a half-day, virtual event on Monday, Oct. 4) and Life Science Summit (LSS – a two-day virtual event Tuesday, Nov. 9 and Wednesday, Nov. 10) that connects innovation, capital, and industry.
See Q&A below with Company co-founder Dr. Hernan A. Bazan.
How do you feel about being selected to participate in the NIH Conference?
It’s obviously a great recognition of the hard science behind the venture. In 2020 we were able to compete with top groups from the major academic and entrepreneurial centers around the U.S. and an NIH (NINDS) Commercialization grant we submitted was scored highly and was funded. The NIH leadership has seen the progress in the past year and has
LSU HSCNO Spin-Out Awarded $1.9M in STTR Fast Track Funding
LSU Health New Orleans
LSU HSCNO Spin-Out Awarded $1.9M in STTR Fast Track Funding
September 28, 2020
The National Institute of Neurological Disorders and Stroke of the National Institutes of Health (NIH) has awarded a $1.9 million Fast-Track Small Business Technology Transfer (STTR) grant to South Rampart Pharma. The New Orleans life science company is developing a new class of non-opioid medicines to relieve pain and reduce fever discovered at and licensed from LSU Health New Orleans, its formal collaborating research institution.
NIH Awards $1.9 million STTR Grant to Fast Track New Class of Non-Opioid Pain Relievers
News-Medical.Net
NIH Awards $1.9 million STTR Grant to Fast Track New Class of Non-Opioid Pain Relievers
September 25, 2020
The National Institute of Neurological Disorders and Stroke of the National Institutes of Health (NIH) has awarded a $1.9 million Fast-Track Small Business Technology Transfer (STTR) grant to South Rampart Pharma. The New Orleans life science company is developing a new class of non-opioid medicines to relieve pain and reduce fever discovered at and licensed from LSU Health New Orleans, its formal collaborating research institution.
Novel Analgesic for Pain Relief Lacks Liver Toxicity
PainRelief.com
Novel Analgesic for Pain Relief Lacks Liver Toxicity
July 24, 2020
Thank you for your kind invitation and opportunity to commend on our paper in press in the European Journal of Medicinal Chemistry entitled ‘A novel pipeline of 2-(benzenesulfonamide)-N-(4-hydroxyphenyl) acetamide analgesics that lack hepatotoxicity and retain antipyresis.’ This is the culmination of a multi-disciplinary effort involving investigators from the United States in Spain in search for a solution to the problem of treating pain more safely.
Researchers Find Alternatives for Acetaminophen Without Liver, Kidney Effects
AJMC
Researchers Find Alternatives for Acetaminophen Without Liver, Kidney Effects
July 20, 2020
The coronavirus disease 2019 pandemic presents a new challenge: patients have severe flu-like symptoms, but the virus can also cause renal failure. Doctors and patients need analgesics that go easy on the liver and kidneys but are not addictive, and this week researchers at LSU Health New Orleans Neuroscience Center of Excellence announced they have discovered a new class of drugs that can do the job.
South Rampart Pharma Identifies New Class of Non-Opioid Pain Medicines in European Journal of Medicinal Chemistry Publication
BioSpace
South Rampart Pharma Identifies New Class of Non-Opioid Pain Medicines in European Journal of Medicinal Chemistry Publication
July 14, 2020
South Rampart Pharma, LLC (“South Rampart” or “the Company”), a company committed to improving the lives of people suffering from pain by developing a new class of non-opioid pain medicines, today announced a peer-reviewed publication detailing the identification and characterization of a new class of compounds able to reduce pain and fever without abuse potential or the liver and kidney toxicity associated with over the counter pain medicines such as acetaminophen.
Research Roundup: COVID-19 Immunity, Stomach Acid Susceptibility and More
BioSpace
Research Roundup: COVID-19 Immunity, Stomach Acid Susceptibility and More
July 10, 2020
Investigators at LSU Health New Orleans Neuroscience Center of Excellence identified a new class of pipeline drugs to relieve pain and reduce fever. Furthermore, they appear to have decreased risk of addiction or damage to the liver or kidneys. In two models, the drugs, which are similar to acetaminophen, but do not appear to damage the liver or kidneys, decreased pain and reduced fever. The intellectual property has been licensed from LSU to the life science startup South Rampart Pharma, which is working to develop the drug in late preclinical development.
Researchers Developing Safer Version of Acetaminophen
Pain News Network
Researchers Developing Safer Version of Acetaminophen
July 8, 2020
Researchers at Louisiana State University have created a new type of analgesic that is similar to acetaminophen but can relieve pain and reduce fever without the risk of liver or kidney damage.
Novel class of non-addictive analgesics demonstrate safety in animals
Drug Target Review
Novel class of non-addictive analgesics demonstrate safety in animals
July 7, 2020
To overcome the issues of current analgesics, researchers reveal a new class of non-narcotic pipeline drugs based on acetaminophen. Acute and chronic pain management is a growing global health burden. With the opioid epidemic still on the rise, and nephro- and hepatotoxicity linked to prolonged use of non-narcotic pain medications, novel analgesics (pain killers) are desperately needed.
Team Synthesizes Safer Nonaddictive Analgesics
Technology Networks
Team Synthesizes Safer Nonaddictive Analgesics
July 7, 2020
Researchers at LSU Health New Orleans Neuroscience Center of Excellence and colleagues have discovered a new class of pipeline drugs to relieve pain and reduce fever without the danger of addiction or damage to the liver or kidneys. The research is published online in the European Journal of Medicinal Chemistry.
Safer Class of Painkillers Identified
MedNews
Safer Class of Painkillers Identified
July 7, 2020
A new class of pain medication has been identified which has a lower risk for addiction or to cause damage to internal organs. This discovery was reported by researchers at LSU Health New Orleans Neuroscience Center of Excellence and published online. The hope is that they will be safer than opioids and more effective.
They discover a new class of pain relievers that do not harm the liver or kidneys
Infosalus
They discover a new class of pain relievers that do not harm the liver or kidneys
July 7, 2020
Researchers at LSU Health’s New Orleans Center of Excellence in Neuroscience have discovered a new class of pain relievers to relieve pain and reduce fever without the danger of addiction or liver or kidney damage.
A new class of pipeline drugs to relieve pain and reduce fever without the danger of addiction or damage
Innovation Toronto
A new class of pipeline drugs to relieve pain and reduce fever without the danger of addiction or damage
July 6, 2020
Researchers at LSU Health New Orleans Neuroscience Center of Excellence and colleagues have discovered a new class of pipeline drugs to relieve pain and reduce fever without the danger of addiction or damage to the liver or kidneys. The research is published online in the European Journal of Medicinal Chemistry.
LSU Health New Orleans discovers new class of safer analgesics
EurekAlert!
LSU Health New Orleans discovers new class of safer analgesics
July 6, 2020
Researchers at LSU Health New Orleans Neuroscience Center of Excellence and colleagues have discovered a new class of pipeline drugs to relieve pain and reduce fever without the danger of addiction or damage to the liver or kidneys. The research is published online in the European Journal of Medicinal Chemistry. Current drugs have unwanted side effects. Opioids can not only cause addiction; recent studies have shown they can be no more effective at relieving pain than non-narcotic drugs. Non-steroidal anti-inflammatories (NSAIDs) can cause kidney damage. Acetaminophen is an effective drug, but overuse can result in liver damage.
New class of safer analgesics discovered
ScienceDaily
New class of safer analgesics discovered
July 6, 2020
Researchers at LSU Health New Orleans Neuroscience Center of Excellence and colleagues have discovered a new class of pipeline drugs to relieve pain and reduce fever without the danger of addiction or damage to the liver or kidneys. The research is published online in the European Journal of Medicinal Chemistry. Current drugs have unwanted side effects. Opioids can not only cause addiction; recent studies have shown they can be no more effective at relieving pain than non-narcotic drugs. Non-steroidal anti-inflammatories (NSAIDs) can cause kidney damage. Acetaminophen is an effective drug, but overuse can result in liver damage.
South Rampart Pharma to Present at 2023 BIO CEO & Investor Conference
Jan. 31, 2023
Hernan Bazan, MD, FACS, CEO and Co-Founder, will provide a company update
Dr. Bazan will also participate in a panel on pain therapeutics innovation with a VP of Industry Research from BIO and Program Directors from NIH and the U.S. Pain Foundation
South Rampart Pharma (“South Rampart” or the “Company”), a clinical-stage life science company advancing innovative non-opioid medications for the treatment of pain, today announced that Hernan Bazan, MD, FACS, CEO and Co-Founder of South Rampart Pharma and the Endowed John Ochsner Professor of Cardiovascular Innovation at the Ochsner Clinic, will present at the BIO CEO & Investor Conference on Monday, February 6.
Dr. Bazan’s presentation will highlight the recent company developments on its novel non-opioid lead asset, ongoing pipeline progress, clinical trial updates and anticipated milestones. Details about the presentation are as follows:
Presenter: Hernan Bazan, MD, FACS,
South Rampart Pharma Announces Presentation at Arrowhead’s 16th Annual Pain Therapeutics Summit
Oct. 21, 2022
South Rampart Pharma (“South Rampart” or the “Company”), a clinical-stage life science company advancing innovative medications for the treatment of pain, today announced that Hernan Bazan, MD, FACS, CEO and Co-Founder of South Rampart Pharma and the Endowed John Ochsner Professor of Cardiovascular Innovation at the Ochsner Clinic, will present at Arrowhead’s 16th Annual Pain Therapeutics Summit.
Taking place in Washington, DC, on November 14-15, 2022, the Pain Therapeutics Summit is the US’s premier conference covering pain research and emerging therapeutics. Leaders from the biopharmaceutical industry, academia, and the NIH attend the conference to learn about the latest advances in treating various kinds of pain and network with colleagues from industry, academia, clinical research organizations, and government.
Dr. Bazan’s presentation, “Overcoming the Liver Toxicity Associated with Acetaminophen Via a New Class of Small Molecule Non-Opioids,” will highlight the ongoing clinical development of novel non-opioid small molecule SRP-001 for the treatment
South Rampart Pharma Issued Composition of Matter Patent for Novel Non-Toxic Treatment for Pain
Oct. 4, 2022
– New patent grant further secures South Rampart’s competitive position in next-generation and disruptive investigational drugs for acute pain –
South Rampart Pharma (“South Rampart” or the “Company”), a clinical-stage life science company advancing innovative medications for the treatment of pain, today announced the issuance of a composition of matter US patent No. 11,458,142 for its novel, non-opioid, and non-liver toxic treatments for pain. The issued patent covers a library of novel small molecules, including the Company’s lead program, SRP-001, which is currently being studied in a two-part randomized, double-blind, placebo-controlled study Phase 1 study evaluating safety, tolerability, and pharmacokinetics, with data expected early in 2023.
This issued patent adds to the Company’s growing patent portfolio, which includes ‘Compositions and methods for ameliorating pain and reducing fever’ US patent No. 11,007,199. The Composition of Matter patent issued today has been nationalized in key world markets. South
South Rampart Pharma Receives Year 3 of NIH Fast-Track STTR Commercialization Grant
Sept. 22, 2022
South Rampart Pharma (“South Rampart” or the “Company”), a clinical-stage life science company advancing innovative medications for the treatment of pain and fever, today announced that it received a Notice of Award from the National Institutes of Health (NIH) regarding Year 3 of its Small Business Technology Transfer (STTR) grant.
The NIH grant is entitled ‘Novel non-narcotic analgesic for acute and chronic pain.’ South Rampart Pharma will receive the Year 3 incremental Award of the $1.9M grant administered through the NIH’s National Institute of Neurological Disorders and Stroke (NINDS), which will continue to help support the development of SRP-001, the Company’s lead drug candidate.
SRP-001 is a novel, non-opioid small molecule with the potential to overcome many risks associated with current pain medicines, including the liver toxicity of acetaminophen. Importantly, SRP-001 mirrors acetaminophen’s clinically validated mechanism of action while simultaneously muting the biological activity that causes liver toxicity. South Rampart Pharma is
South Rampart Pharma Announces Late-Breaking Presentation at IASP 2022 World Congress on Pain
Aug. 25, 2022
South Rampart Pharma (“South Rampart” or the “Company”), a clinical-stage life science company advancing innovative medications for the treatment of pain and fever, today announced that the Company will present a late-breaking abstract at the International Association for the Study of Pain (IASP) 2022 World Congress on Pain, which will take place on September 20-23, 2022, in Toronto, Canada.
The late-breaking presentation, entitled “Novel Non-Opioid Analgesic for Acute and Chronic Pain: From Discovery to Phase 1 Trial,” will chronicle the invention and development of SRP-001 (previously known as SRP-3D (DA)). Central to SRP-001’s therapeutic differentiation, this non-opioid investigational pain medication exhibits comparable, if not better, efficacy as similar approved drugs but notably does not exhibit their liver or kidney toxicity. South Rampart’s CEO and Co-founder, Hernan Bazan, MD, FACS, will deliver the presentation.
“I’m delighted to have this opportunity to showcase the groundbreaking work we’ve done with SRP-001,” commented Dr. Bazan. “Liver toxicity
South Rampart Pharma Announces Appointment of Josh Blacher as Chief Financial Officer
Aug. 16, 2022
South Rampart Pharma (“South Rampart” or the “Company”), a clinical-stage life science company advancing innovative medications for the treatment of pain and fever, today announced the appointment of Josh Blacher as the company’s Chief Financial Officer. In this capacity, Mr. Blacher will be responsible for the Company’s finance and accounting department, as well as launch a robust corporate development effort.
Mr. Blacher brings to South Rampart Pharma over twenty years of leadership experience in senior positions in the healthcare and capital markets sectors. Hernan Bazan, M.D., F.A.C.S., CEO and Co-Founder of South Rampart Pharma and The Endowed John Ochsner Professor of Surgery at the Ochsner Clinic, commented, “We are thrilled to welcome Josh to our team. Josh brings us a valuable combination of executing growth capital initiatives as well as strategic collaborations with biopharmaceutical partners.” Dr. Bazan continued, “As we ready for Phase 2 clinical trials of our novel non-opioid
South Rampart Pharma Achieves Development Milestone and Advances to Phase II of Active NIH Fast-Track STTR Commercialization Award
May 4, 2022
$1.9 million NIH fast-track STTR grant fuels next stage of clinical program dedicated to the development of a novel non-opioid approach to pain management
Lead program SRP-3D (DA) advances in ongoing Phase 1 clinical trial with data expected in the third quarter of 2022
South Rampart Pharma (“South Rampart” or the “Company”), a clinical-stage life science company advancing innovative medications for the treatment of pain and fever, today announced it achieved milestones outlined in the Phase I portion of its Small Business Technology Transfer (STTR) grant (1R42NS119103) received from the National Institutes of Health (NIH) and advanced to the Phase II portion of its NIH grant. The ‘fast-track’ combined Phase I/II award provides for $1.9 million of funding to support the ongoing clinical development of the Company’s lead small molecule, SRP-3D (DA), a novel non-opioid therapeutic candidate. South Rampart Pharma currently is completing the single
South Rampart Pharma Announces Patient Enrollment and Dosing Underway in Phase 1 Study Evaluating Novel Non-Opioid Approach to Pain with Lead Program, SRP-3D (DA)
March 23, 2022
SRP-3D (DA) has demonstrated a compelling safety profile over currently available pain medications
Potential to address the significant unmet need for new, safe, effective, and non-opioid pain medications
Development program funded by the National Institutes of Health (NIH) through a Small Business Technology Transfer (STTR) Fast Track Grant
Topline results expected Q3 2022
South Rampart Pharma (“South Rampart” or the “Company”), a clinical-stage life science company focused on advancing innovative medications for the treatment of pain and fever, announced today patient enrollment and dosing in its Phase 1 study evaluating SRP-3D (DA) for pain is underway.
“We are committed to improving the lives of people suffering from acute, chronic, or neuropathic pain by developing a new class of small molecule, non-opioid pain medicines. To date, SRP-3D (DA) has shown promising efficacy in reducing both pain and fever while lacking the liver and kidney toxicity associated
NIH STTR Grant To Fast Track New Class Of Pain Reliever Without Addiction Or Toxicity
Sep 25, 2020
The National Institute of Neurological Disorders and Stroke of the National Institutes of Health (NIH) has awarded a $1.9 million Fast-Track Small Business Technology Transfer (STTR) grant to South Rampart Pharma. The New Orleans life science company is developing a new class of non-opioid medicines to relieve pain and reduce fever discovered at and licensed from LSU Health New Orleans, its formal collaborating research institution.
The grant will fund late-stage, pre-clinical development of the new analgesic/antipyretic and will also support continued collaboration with LSU Health New Orleans Neuroscience Center of Excellence on pain mechanisms. A paper describing the patented new drug was recently published in the European Journal of Medicinal Chemistry.
“The safe treatment of acute and chronic pain is one of the most prevalent and costly public health issues worldwide,” said Hernan Bazan, MD, DFSVS, FACS, CEO and co-founder of South Rampart Pharma, and Professor of Surgery at the Ochsner
South Rampart Pharma Identifies New Class of Non-Opioid Pain Medicines in European Journal of Medicinal Chemistry Publication
July 10, 2020
South Rampart Pharma, LLC (“South Rampart” or “the Company”), a company committed to improving the lives of people suffering from pain by developing a new class of non-opioid pain medicines, today announced a peer-reviewed publication detailing the identification and characterization of a new class of compounds able to reduce pain and fever without abuse potential or the liver and kidney toxicity associated with over the counter pain medicines such as acetaminophen. The paper, published in the European Journal of Medicinal Chemistry, is available as open access and entitled, “A novel pipeline of 2-(benzenesulfonamide)-N-(4-hydroxyphenyl) acetamide analgesics that lack hepatotoxicity and retain antipyresis1.”
“We are currently working to finalize the preclinical data package necessary to submit our lead molecule for the first Investigational New Drug (IND) application by the third quarter of 2020, followed by the rapid initiation of Phase 1 clinical trials to evaluate safety. Ongoing preclinical studies have
LSU Health New Orleans Discovers New Class of Safer Analgesics
Jul 6, 2020
Researchers at LSU Health New Orleans Neuroscience Center of Excellence and colleagues have discovered a new class of pipeline drugs to relieve pain and reduce fever without the danger of addiction or damage to the liver or kidneys. The research is published online in the European Journal of Medicinal Chemistry.
Current drugs have unwanted side effects. Opioids can not only cause addiction; recent studies have shown they can be no more effective at relieving pain than non-narcotic drugs. Non-steroidal anti-inflammatories (NSAIDs) can cause kidney damage. Acetaminophen is an effective drug, but overuse can result in liver damage.
The research team, led by Drs. Hernan A. Bazan, a professor in the Department of Surgery and Program Director of the Vascular Surgery Fellowship at Ochsner Clinic, and Surjyadipta Bhattacharjee, a post-doctoral researcher at the LSU Health New Orleans Neuroscience Center of Excellence, set out to discover what causes the liver damage associated with
A novel pipeline of 2-(benzenesulfonamide)-N-(4-hydroxyphenyl) acetamide analgesics that lack hepatotoxicity and retain antipyresis
European Journal of Medicinal Chemistry Sept 2020
