Global need for safer pain medicine

Pain management is one of the most prevalent and costly public health issues worldwide. In the U.S., pain affects more adults than diabetes and cancer combined1, 2, and costs the healthcare system an estimated $635 billion annually3. Current medications are either highly addictive or cause harm to the liver and kidney. There is a great unmet need for new, safe, effective and non-opioid pain medications.


Worldwide an estimated 20% of adults suffer from pain and 10% of adults are diagnosed with chronic pain each year3.

Worldwide, 1 in 5 people have moderate to severe chronic pain4.

An estimated 20.4% (50.0 million) of U.S. adults experience chronic pain5 and more than 76 million, or 1 in every 4 Americans, have suffered from pain that lasts longer than 24 hours6.

people in circle

Economic Burden

Pain is cited as the most common reason Americans access the healthcare system and is a leading cause of disability, making it a major contributor to healthcare costs6.

Patients with pain conditions consume close to twice as much healthcare resources as the general population7.

In 2018, the U.S. spent $10,586 on healthcare per person. That is two times the amount of the country with the second highest expenditure8.

The United States has the most expensive healthcare system and moving forward the U.S. healthcare system cannot afford and may not support more expensive therapies.

Per capita health expenditure in selected countries in 2018

pain medicine chart

Opioid Epidemic



(In July 2021) the Centers for Disease Control and Prevention (CDC) released preliminary data that opioid drug overdose deaths rose by nearly 30% in 2020 to 93,0009.



The opioid crisis cost the U.S. economy at least $631 billion in 201910.

The rising opioid crisis in the U.S. highlights the urgency for a new selective pain-relieving compound with minimal potential for dependence and addiction.

Significant Unmet Need & Market Opportunity

There is a significant market for new, selective, non-narcotic compounds to treat pain.

global market pain management chart

In 2018, the global market for pain management pharmaceuticals was worth $38.9B and is projected to grow to $52.1B by 202411.

us market analgesics chart

The U.S. market for analgesics is estimated to be more than $5.9B by 202312 and by 2020 the worldwide ApAP market is expected to be around $1B13.

Between November 2017 - November 2019, 38 early-stage (series A & B) financings were completed for privately-held companies within the chronic, acute and neuropathic pain sectors, and over $560M capital was invested.

South Rampart Pharma’s solution is a novel small molecule, introducing a value product that will be low cost and accessible to many patients.


  1. Relieving Pain in America. (2011). National Academy of Sciences. doi: 10.17226/13172
  2. Goldberg, D. S., & Mcgee, S. J. (2011). Pain as a global public health priority. BMC Public Health, 11(1). doi: 10.1186/1471-2458-11-770
  3. Gaskin, D. J., & Richard, P. (2012). The Economic Costs of Pain in the United States. The Journal of Pain, 13(8), 715–724. doi: 10.1016/j.jpain.2012.03.009
  4. Goldberg, D. S., & Mcgee, S. J. (2011). Pain as a global public health priority. BMC Public Health, 11(1). doi: 10.1186/1471-2458-11-770
  5. Prevalence of Chronic Pain and High-Impact Chronic Pain Among Adults – United States, 2016. (2019, September 16). Retrieved from
  6. Partners for Understanding Pain. (n.d.). TOOL KIT – The ACPA Health Care Professionals September 2019. Retrieved from Tool-Kit-2019-Final-8-27-19.pdf.
  7. Henschke, N., Kamper, S. J., & Maher, C. G. (2015). The Epidemiology and Economic Consequences of Pain. Mayo Clinic Proceedings, 90(1), 139–147. doi: 10.1016/j.mayocp.2014.09.010
  8. McCarthy, N. (2019, August 8). How U.S. Healthcare Spending Per Capita Compares With Other Countries [Infographic]. Retrieved from
  9. Centers for Disease Control and Prevention. Provisional drug overdose death counts. National center for health statistics https://www.Cdc.Gov/nchs/nvss/vsrr/drug-overdose-data.Htm#dashboard. 2021
  10. ltd, R. and M. (2019, June). Pain Management Drugs Market: Global Industry Trends, Share, Size, Growth, Opportunity and Forecast 2019-2024. Retrieved from
  11. Doughman, E. (2019, May 3). U.S. Painkiller Market to Reach $5.9 Billion by 2023. Retrieved from
  12. Market Research Store. (2016, January 28). Global Acetaminophen (Paracetamol) Market Set for Rapid Growth, To Reach Around USD 999.4 Million by 2020. Retrieved from
  13. Zion Research Analysis, 2015.